Uterotrophic Assay of Percutaneous Lavender Oil in Immature Female Rats
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چکیده
منابع مشابه
Immature rat uterotrophic assay of bisphenol A.
We used the immature rat uterotrophic assay to determine the estrogenicity of bisphenol A (BPA). We administered BPA (in sesame oil) to rats subcutaneously (sc; 0, 8, 40, and 160 mg/kg/day) or orally (0, 40, 160, and 800 mg/kg/day) for 3 days beginning on postnatal day (PND) 18; rats were sacrificed 24 hr after the last administration. Uterine wet, blotted, and relative weights increased in all...
متن کاملPercutaneous absorption of lavender oil from a massage oil
In the present study, the percutaneous absorption of the essential oil of lavender from a massage oil was investigated. It was shown that lavender oil penetrates the skin of a male subject. Within five minutes of finishing, the massage traces of linalool (1) and linalyl acetate (2) as the main constituents of lavender oil could be detected in the blood. After 20 minutes, 100 ng/ml for 2 and 121...
متن کاملCommercial cows' milk has uterotrophic activity on the uteri of young ovariectomized rats and immature rats.
Cows' milk contains considerable quantities of estrogens, mainly in the form of estrone sulfate (ES). To determine whether the commercial milk has any biologically significant hormonal effects, 2 series of uterotrophic tests were performed, 1 with young ovariectomized rats and the other with sexually immature rats. Thirty-six rats were used for each test. They were divided into 3 groups of 12 a...
متن کاملSensitivity of the immature rat uterotrophic assay to mixtures of estrogens.
We have evaluated whether mixtures of estrogens, present in the mix at doses that are individually inactive in the immature rat uterotrophic assay, can give a uterotrophic response. Seven chemicals were evaluated: nonylphenol, bisphenol A (BPA), methoxychlor, genistein (GEN), estradiol, diethylstilbestrol, and ethinyl estradiol. Dose responses in the uterotrophic assay were constructed for each...
متن کاملUterotrophic activity of bisphenol A in the immature rat.
Bisphenol A (BPA) is active in immature AP rat uterotrophic assays when evaluated using either the oral or the subcutaneous (sc) injection routes of exposure (three daily administrations of 400-800 mg/kg BPA). Premature vaginal opening was seen for 8 of 14 animals exposed to 600 and 800 mg/kg BPA by sc injection. Vaginal opening was not produced by BPA in the gavage studies. These results are c...
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ژورنال
عنوان ژورنال: International Journal of Toxicology
سال: 2013
ISSN: 1091-5818,1092-874X
DOI: 10.1177/1091581812472209